Investigating the Effect of Zinc Chloride to Control External Bleeding in Rats

Nouri, S. and Sharif, M. R. and Tabatabaei, F. and Farokhi, S. (2014) Investigating the Effect of Zinc Chloride to Control External Bleeding in Rats. Nurs Midwifery Stud, 3 (3). e22063.

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Abstract

Background: Despite all progresses in surgical science, bleeding caused by traffic accidents is still a challenge for surgeons to save patients’ lives. Therefore, introducing an effective method to control external bleeding is an important research priority. Objectives: This study aimed to compare haemostatic effect of zinc chloride and simple suturing to control external bleeding. Materials and Methods: In this animal model study, 60 male Wistar rats were used. An incision (two cm in length and half a cm in depth) was made on shaved back of rats. The hemostasis time was measured once using zinc chloride with different concentrations (5%, 10%, 15%, 25%, and 50%) and then using simple suturing. Skin tissue was assessed for pathological changes. Due to abnormal distribution of variables in Kolmogorov-Smirnov test, the data was analyzed using Kruskal-Wallis test Mann-Whitney U tests. Results: In all the groups, complete hemostasis occurred. Hemostasis times of different concentrations of zinc chloride were significantly less than that of the control group (P < 0.001). Conclusions: Zinc chloride was effective to control external bleeding in rats.

Item Type: Article
Subjects: Medicine
Divisions: Nursing and Midwifery Studies journal
Depositing User: ART . editor
Date Deposited: 03 May 2017 16:47
Last Modified: 12 Jul 2017 14:15
URI: http://eprints.kaums.ac.ir/id/eprint/1299

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