The effects of onion consumption on treatment of metabolic, histologic, and inflammatory features of nonalcoholic fatty liver disease

Emamat, H. and Foroughi, F. and Eini-Zinab, H. and Taghizadeh, M. and Rismanchi, M. and Hekmatdoost, A. (2016) The effects of onion consumption on treatment of metabolic, histologic, and inflammatory features of nonalcoholic fatty liver disease. Journal of Diabetes and Metabolic Disorders, 15 (1).

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Abstract

Background: The aim of this study was to evaluate the effects of onion powder consumption on treatment of Non-alcoholic Fatty Liver Disease (NAFLD) in an experimental model of disease. Methods: Sprague-Dawley rats were fed high-fat (HF) diet for seven weeks to induce the NAFLD. Then, they were treated by either the same diet (HF), or high-fat diet plus 7 onion powder (HF + onion), or chow diet (control), or chow diet plus 7 onion powder (control + onion)ad libitum for four weeks. Serum levels of fasting glucose, triglyceride, cholesterol, liver enzymes, insulin, and hepatic tumor necrosis factor-alpha (TNF-α) gene expression were determined. Hepatic histology was examined by Hematoxylin and Eosin stain. Results: Dietary food intakes and weigh gain were significantly more in animals fed control + onion diet in comparison to the other groups. Animals fed control or control + onion diet had significantly lower plasma levels of hepatic enzymes, lipid profile, glycemic indices, and hepatic TNF-α gene expression as compared with HF diet fed groups; however, there was no significant difference in the histopathologic features of NAFLD among different groups. Conclusion: Our results indicate that onion consumption can be effective in NAFLD management when it is combined with a healthy diet. © 2016 Hekmatdoost et al.

Item Type: Article
Additional Information: cited By 0
Subjects: Physiology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 08:28
Last Modified: 04 Mar 2017 08:28
URI: http://eprints.kaums.ac.ir/id/eprint/111

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