The effects of Vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD

Asemi, Z. and Raygan, F. and Bahmani, F. and Rezavandi, Z. and Talari, H.R. and Rafiee, M. and Poladchang, S. and Darooghegi Mofrad, M. and Taheri, S. and Mohammadi, A.A. and Esmaillzadeh, A. (2016) The effects of Vitamin D, K and calcium co-supplementation on carotid intima-media thickness and metabolic status in overweight type 2 diabetic patients with CHD. British Journal of Nutrition, 116 (2). pp. 286-293.

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Abstract

This study was conducted to examine the effects of vitamin D, K and Ca co-supplementation on carotid intima-media thickness (CIMT) and metabolic status in overweight diabetic patients with CHD. This randomised, double-blind, placebo-controlled trial was conducted among sixty-six diabetic patients with CHD. Participants were randomly allocated into two groups to take either 5g vitamin D, 90 g vitamin K plus 500 mg Ca supplements (n 33) or placebo (n 33) twice a day for 12 weeks. Fasting blood samples were obtained at the beginning of the study and after the 12-week intervention period to determine related markers. Vitamin D, K and Ca co-supplementation resulted in a significant reduction in maximum levels of left CIMT (-0·04 (sd 0·22) v. +0·04 (sd 0·09) mm, P=0·02). Changes in serum vitamin D (+6·5 (sd 7·8) v. +0·4 (sd 2·2) ng/ml, P<0·001), Ca (+0·6 (sd 0·3) v. +0·1 (sd 0·1) mg/dl, P<0·001) and insulin concentrations (-0·9 (sd 3·1) v. +2·6 (sd 7·2) IU/ml, P=0·01), homoeostasis model for assessment of estimated insulin resistance (-0·4 (sd 1·2) v. +0·7 (sd 2·3), P=0·01), β-cell function (-2·1 (sd 9·0) v. +8·9 (sd 23·7), P=0·01) and quantitative insulin sensitivity check index (+0·007 (sd 0·01) v. -0·006 (sd 0·02), P=0·01) in supplemented patients were significantly different from those in patients in the placebo group. Supplementation resulted in significant changes in HDL-cholesterol (+2·7 (sd 7·0) v. -2·5 (sd 5·7) mg/dl, P=0·002), high-sensitivity C-reactive protein (-1320·1 (sd 3758·3) v. +464·0 (sd 3053·3) ng/ml, P=0·03) and plasma malondialdehyde concentrations (-0·4 (sd 0·5) v. -1·0 (sd 1·1) mol/l, P=0·007) compared with placebo. Overall, vitamin D, K and Ca co-supplementation for 12 weeks among diabetic patients with CHD had beneficial effects on maximum levels of left CIMT and metabolic status. The effect of vitamin D, K and Ca co-supplementation on maximum levels of left CIMT could be a chance finding. © The Authors 2016.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: 25 hydroxyergocalciferol; C reactive protein; calcium; calcium ion; farnoquinone; high density lipoprotein cholesterol; insulin; malonaldehyde; placebo; vitamin D, adult; aged; arterial wall thickness; Article; calcium blood level; cell function; cholesterol blood level; controlled study; diabetic patient; double blind procedure; drug effect; drug mechanism; female; glycemic control; homeostatic model assessment of insulin resistance; human; insulin blood level; ischemic heart disease; major clinical study; male; metabolic equivalent; metabolic parameters; non insulin dependent diabetes mellitus; obesity; oxidative stress; pancreas islet beta cell; patient compliance; protein blood level; Quantitative Insulin Sensitivity Check Index; randomized controlled trial; treatment duration; vitamin blood level
Subjects: Nutrition
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 08:29
Last Modified: 04 Mar 2017 08:29
URI: http://eprints.kaums.ac.ir/id/eprint/109

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