The effects of vitamin D plus calcium supplementation on metabolic profiles, biomarkers of inflammation, oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia

Samimi, M. and Kashi, M. and Foroozanfard, F. and Karamali, M. and Bahmani, F. and Asemi, Z. and Hamidian, Y. and Talari, H.R. and Esmaillzadeh, A. (2016) The effects of vitamin D plus calcium supplementation on metabolic profiles, biomarkers of inflammation, oxidative stress and pregnancy outcomes in pregnant women at risk for pre-eclampsia. Journal of Human Nutrition and Dietetics, 29 (4). pp. 505-515.

Full text not available from this repository.
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....
DOI: UNSPECIFIED

Abstract

Background: The present study was designed to examine the effects of vitamin D plus calcium administration on metabolic profiles and pregnancy outcomes among women at risk for pre-eclampsia. Methods: In a prospective, double-blind, placebo-controlled trial, 60 women at risk for pre-eclampsia were randomised to take either 50 000 IU vitamin D3 every 2 weeks plus 1000 mg day�1 calcium supplements (as calcium carbonate) (n = 30) or to receive placebos at the same times (n = 30) from 20 to 32 weeks of gestation. Fasting blood samples were taken at baseline and 12 weeks after intervention to determine related variables. Newborn anthropometric measurements were determined. Results: Taking combined cholecalciferol and calcium supplements, compared to placebo, led to significant reductions in fasting plasma glucose (FPG) mean (SD) �5.7 (5.5) versus �0.6 (12.6) mg dL�1, P = 0.04, serum insulin concentrations �2.8 (6.0) versus +7.7 (9.8) μIU mL�1, P < 0.001, homeostasis model of assessment-insulin resistance �0.8 (1.3) versus +1.6 (2.2), P < 0.001, homeostatic model assessment-beta cell function �8.2 (25.8) versus +32.6 (41.3, P < 0.001 and a significant rise in quantitative insulin sensitivity check index score +0.02 (0.02) versus �0.02 (0.02, P < 0.001. Additionally, pregnant women who received cholecalciferol plus calcium supplements had increased serum high-density lipoprotein (HDL)-cholesterol +4.6 (8.3) versus �2.9 (7.7) mg dL�1, P = 0.001 and plasma total glutathione (GSH) concentrations +23.4 (124.0) versus �94.8 (130.2) μm, P = 0.001 compared to placebo. However, after adjustment for the baseline levels, maternal age and baseline body mass index, the effects on FPG levels (P = 0.13) and systolic blood pressure (P = 0.13) disappeared. Conclusions: Vitamin D plus calcium administration for 12 weeks had beneficial effects on glycaemic status, HDL-cholesterol, GSH and blood pressure among women at risk for pre-eclampsia. © 2015 The British Dietetic Association Ltd.

Item Type: Article
Additional Information: cited By 0
Subjects: Nutrition
Biochemistry, Genetics and Molecular Biology
Divisions: Faculty of Medicine > Basic Sciences > Department of Nutrition
Depositing User: editor . 2
Date Deposited: 04 Mar 2017 08:40
Last Modified: 04 Mar 2017 08:40
URI: http://eprints.kaums.ac.ir/id/eprint/104

Actions (login required)

View Item View Item